Femoral arterial injection of U62066 did not attenuate the pressor responses to contraction in either group of rats. The pressor responses to static contraction were compared before and after femoral arterial or intrathecal injection of the κ-opioid receptor agonist U62066 (1, 10, and 100 μg). We tested the hypothesis that stimulation of κ-opioid receptors attenuates the exercise pressor reflex in rats with ligated, but not freely perfused, femoral arteries. The effect of stimulation of κ-opioid receptors on the exercise pressor reflex is unknown. The exaggerated reflex in rats with ligated arteries is attenuated by stimulation of μ-opioid and δ-opioid receptors on the peripheral endings of thin-fiber muscle afferents. The exercise pressor reflex is greater in rats with ligated femoral arteries than it is in rats with freely perfused femoral arteries.
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